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[The Fifth Horseman]

core=dynamic

This will increase the emulation speed, altough if the game you're running acquires a sudden tendency to crash - switch it back to normal.

Also, I recommend the following cycle settings:
cycles=12000
cycleup=1000
cycledown=1000
This is more or less an optimum for most games on my Sempron 2500+, and can be easily adjusted.
Sometimes older games may need far lower cycle values, but in those cases even the default 3000 is typically too fast for them.