Well, Jigsaw kidnaps his victims and puts them in a danger lair, not just one room sometimes, where they have to follow his riddles to get out, sometimes having to kill each other, or mame themselves to get out. But each room has a danger to it. Soemtimes he doesn't even put them in a danger room, as evidenced by the venus fly trap incident where jigsaw surgically hid a key under a mans eye, the key was to a head trap that if not activated by the key, would snap a hundred needles into the mans head. The man was not successful in getting the key. Usually each situation has three solutions. One gets the victim killed. One where the victim gets himself killed or mamed. Or one around both. I believe Holmes could find a way around both. Jigsaw also has traps designed to take care of any people sent to rescue any victims.
Another thing though is the fact that, as you said, Holmes is strong. I don't see how Jigsaw could possibly kidnap a full grown Holmes. It's like trying to survive a Chuck Norris roundhouse kick. As far as irony, one of the best ironys would be for Jigsaw to end up getting caught in one of his own traps. I think that'd really "hoist him up by his own petard".
One big thing though is the fact that, if Holmes was put in the danger lair scenario, Jigsaw would have other people there, and I'm not sure how Holmes would handle that part of the situation.